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mHSPC
Inclusion Criteria Control
Active Arm
N 1ary
ep
Expected
ARCHES
NCT02677896
Naïve
or
ADT + Doc x6 <2 m
ADT
Ctrl +
Enza
1150 rPFS
Oct 2018
ENZAMET
NCT02446405
Naïve
ADT
/
ADT + Doc
ADT
±
Doc +
Enza
1125 OS Sep 2020
PEACE-1
NCT01957436
Naïve
ADT + Doc
ADT + Doc +
Abi
ADT + Doc +
RT
ADT + Doc +
Abi + RT
1168 OS &
rPFS
Oct
2018
TITAN
NCT02489318
Naïve* or
ADT + Doc x 6 <2 m
ADT
ADT +
Apalutamide
1052 OS &
rPFS
Nov 2020
ARASENS
NCT02799602
Naïve
ADT + Doc
ADT + Doc +
ODM-201
1303 OS Aug 2022
SWOG 1216
NCT01809691
Naïve
ADT +
bicalutamide
ADT + TAK-700
1313 OS Mar 2022
*Excludes Visceral or LN only metastasis.