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Enzalutamide

160 mg QD

+ LHRHa

(or orchidectomy)

until progression

n=1125

Metastatic prostate

cancer

ECOG 0–2

Commencing ADT

NSAA + LHRHa

(or orchidectomy)

until progression

R

1:1

Primary Objective

-

OS

Phase III Randomized study in mHSPC