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Enzalutamide

160 mg QD

+ LHRHa

(or orchidectomy)

until progression

n=1125

Metastatic prostate cancer

ECOG 0–2

First line

De Novo/Relapsed

Low & High volume

Docetaxel

early- allowed

NSAA + LHRHa

(or orchidectomy)

until progression

R

1:1

Phase III Randomized study in mHSPC