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Enzalutamide

160 mg QD

+ LHRHa

(or orchidectomy)

until progression

n=1125

Metastatic prostate

cancer

ECOG 0–2

Commencing ADT

NSAA + LHRHa

(or orchidectomy)

until progression

R

1:1

STRATIFICATION:

High Volume Disease

(yes vs. no)

Early Use of Docetaxel

Concomitant “Anti-

Resorptive” Therapy

to Delay SRE,

Study Site

Co-Morbidities

Phase III Randomized study in mHSPC