Enzalutamide
160 mg QD
+ LHRHa
(or orchidectomy)
until progression
n=1125
Metastatic prostate
cancer
ECOG 0–2
Commencing ADT
NSAA + LHRHa
(or orchidectomy)
until progression
R
1:1
•
STRATIFICATION:
–
High Volume Disease
(yes vs. no)
–
Early Use of Docetaxel
–
Concomitant “Anti-
Resorptive” Therapy
to Delay SRE,
–
Study Site
–
Co-Morbidities
Phase III Randomized study in mHSPC