18 / 34
N
OS
PFS
RR
Placebo Aflibercept Placebo Aflibercept Placebo Aflibercept
VELOUR ITT
1226
12.1
13.5
4.7
6.9
11.8%
19.9%
Full biomarker
population
482
11.4
12.9
4.3
6.8
12.4%
19.3%
BRAF
wt
446 12.4
(10.7 – 15.1)
13.0
(12.4 – 15.9)
4.5
(4.1 – 5.8)
6.9
(6.2 – 7.7)
14.0%
(
9.1 – 20.3)
23.5%
(16.9 – 31.1)
HR (95%CI)
0.84 (0.67 – 1.05)
0.76 (0.61 – 0.94)
1.76 (0.99 – 3.14)
BRAF
mutant
36
5.5
(3.5 – 10.6)
10.3
(5.3 – NA)
2.2
(1.4 – 8.3)
5.5
(2.7 – NA)
15.4%
(1.9 - 45.5)
30.0%
(6.7 – 65.2)
HR (95%CI)
0.42 (0.16-1.09)
0.59 (0.22 – 1.58)
1.26 (0.14 – 11.01)
Interaction test
0.08
0.29
0.98
BRAF
mutations in Velour
Tejpar, World GI 2017