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median

PS

The subset of patients available for this RNA signature, (n=439, with only n=363 overlapping with the subset with

available DNA data) is not representative any more of the ITT in terms of treatment effects:

HR in the population with RNA samples available is 0.92 (95%CI: 0.74 – 1.16) vs

HR=0.82 (95%CI: 0.71 -0.93) in the ITT population

Pending: RNA Exploratory Validation

Tejpar, World GI 2017

CMS and other gene expression signatures pending