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RAS
mutations in Velour
N
OS
PFS
RR
Placebo Aflibercept Placebo Aflibercept Placebo Aflibercept
VELOUR ITT
1226 12.1
13.5
4.7
6.9
11.8% 19.9%
Biomarker popul.
482 11.4
12.9
4.3
6.8
12.4% 19.3%
RAS
wt
218 11.7
(10.1 – 15.9)
16.0
(12.7 – 22.8)
4.5
(3.9 – 5.8)
7.7
(6.7 – 9.7)
10.9
(5.34 – 19.1
)
28.6
(18.6 – 38.2
)
HR (95%CI)
0.70 (0.50 – 0.97)
0.67 (0.49 – 0.93)
3.63 (1.56 – 8.43)
RAS
mutant
264 11.2
(9.9 – 13.8)
12.6
(10.7 – 14.5)
4.2
(3.9 – 5.9)
6.5
(5.4 – 7.2)
13.6
(7.8 – 21.5)
12.7
(7.14 – 20.4)
HR (95%CI)
0.93 (0.7-1.23)
0.80 (0.60 – 1.07)
0.94 (0.43 – 2.07)
Interaction test
0.13
0.29
0.03
Tejpar, World GI 2017