Update and new trends in antiemetic therapy and supportive care

NEPA PHASE III TRIAL IN AC CHEMO

Study Design

• Phase III, multinational, randomized, double-blind study in chemotherapy-

naïve patients undergoing Anthracycline + CTX chemo

• Patients randomized to receive one of the following regimens, on Day 1 only

(no continued steroids):

Oral NEPA + Oral DEX 12 mg

(NEPA = NETU 300 mg + PALO 0.50 mg)

Oral PALO 0.50 mg + Oral DEX 20 mg

N = 1455

•

NEPA (netupitant + palo) or PALO were administered 60 minutes prior to chemotherapy; DEX was given orally at 30

minutes prior to chemotherapy

•

No other antiemetic was given as part of either study regimen after Day 1

Reference: Aapro M et al. Ann Oncol. 2014; 25:1328-33

Randomized

1:1