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NEPA Conclusions

• The fixed-dose combination, single dose oral treatment:

– Is based on rigorous dosing studies (pre-clinical and clinical)

– Combines agents with long plasma half-lives and long durations of activity

– Is rigorously tested for safety

– Is associated with competitive antiemetic activity

• Multiple cycles

• Cisplatin

• “AC” Chemotherapy

• NEPA directly addresses the key issues of:

– Guideline compliance in prescribing

– Enhancing ease of patient adherence and education