Update and new trends in antiemetic therapy and supportive care

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Controlling Emesis with Chemotherapy

- New Agents -

Some references:

1

Rapoport, et al.

Lancet Oncol

2015.

2

Schwarzberg, et al.

Lancet Oncol

2015.

3

Aapro, et al

. Ann Oncol

2014;

4

Gralla, et al.

Ann Oncol

2014;

5

Navari et al.

N Engl J Med

2016

• Rolapitant

1,2

• NK

1

receptor antagonist with different metabolic pathway

• Highly selective agent

• Single oral dosing (IV formulation in some countries, but hypersensitivity issues)