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Developing new antiemetic agents to address
recognized issues in controlling emesis
• Even with marked progress in effective antiemetic prophylaxis, many patients still experience
emesis with chemotherapy, particularly during the delayed phase
– Reasons for emetic failure include:
• Patients are not always prescribed effective guideline-based antiemetic drug regimens
• Patients frequently do not adhere to delayed emesis regimens
• Antiemetic guidelines result in significant improvement in the control of emesis with better
resource utilization
• There is a need to enhance guideline-consistent practice and to assist patient adherence
• An effective single dosing, all oral regimen given immediately prior to chemotherapy could
provide maximally convenient care enhancing effectiveness
Evidence of safety and effective control over multiple chemotherapy cycles: Cisplatin, AC, QME