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Controlling Emesis with Chemotherapy
- New Agents -
•
NEPA
3, 4
• Fixed-dose combination of netupitant (NK
1
receptor antagonist) + palonosetron (5HT
3
receptor antagonist)
• Highly selective agents
• Single oral dosing for both acute and delayed emesis (IV formulation in some countries)
• Multiple positive safety studies
Some references:
1
Rapoport, et al.
Lancet Oncol
2015.
2
Schwarzberg, et al.
Lancet Oncol
2015.
3
Aapro, et al
. Ann Oncol
2014;
4
Gralla, et al.
Ann Oncol
2014;
5
Navari et al.
N Engl J Med
2016