Estado del arte con el tratamiento con inhibidores de BRAF + MEK

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IC50 = 2,5 nM
-2 0 2 4
0
5 0
1 0 0
1 5 0
T r a m e t in ib
L o g [d ru g ] (n M )
% o f c e lls
0 1 2 3 4 5
0
5 0
1 0 0
1 5 0
D a b r a f e n ib
L o g [d ru g ] (n M )
% o f c e lls IC50= ~ 33 µM
-2 0 2
0
5 0
1 0 0
1 5 0
C is -P t
L o g [d ru g ] (n M )
% o f c e lls
IC50= 13 µM
Note: IC50 values are averaged and / or rounded
IC50= ~ 120 µM
-2 0 2
0
5 0
1 0 0
1 5 0
C a r b o p la t in
L o g [d ru g ] ( µM )
% o f c e lls
-2 0 2 4
0
5 0
1 0 0
1 5 0
P a c lit a x e l
L o g [d ru g ] (n M )
% o f c e lls
IC 50= 0,56 nM
0 1 2 3
0
5 0
1 0 0
1 5 0
T e m o z o lo m id e
L o g [d ru g ] ( µ M )
% o f c e lls IC50 > 635 µM
SENSITIVE
VERY RESISTANT
RESISTANT
VERY RESISTANT
SENSITIVE
VERY RESISTANT
Jordi Berenguer (Rosell`s lab).