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Acctivity on RAF dimers inhibition
Yao Cancer cell 2015
In vitro
analysis of phospho-ERK inhibition in RAF dimers and monomers:
- Melanoma cell lines driven by
RAF monomers : SK-MEL-239
- Melanoma cell lines driven by
RAF dimers : SK-MEL-239 C4
-
IC50
is the concentration needed to inhibit 50% of phospho-ERK in cell lines
Vemurafenib
Dabrafenib
Encorafenib
SK-MEL-239
71
13
14
SK-MEL-239 C4
6142
643
287
IC
50
of p-ERK (nM)