Estado del arte con el tratamiento con inhibidores de BRAF + MEK

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Yao Cancer cell 2015
RAF inhibitors WT RAF dimer 2nd
site/V600E monomer
Vemurafenib >135
Dabrafenib 83.4
Encorafenib 58.3
Concentration is needed to inhibit the second RAFwt dimer
In vitro analysis of phospho-ERK inhibition in RAF dimers:
- The value reported in the table is the fold change concentration needed to inhibit the second
dimer in wild type healthy cells
RAF dimers inhibition