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Overall Survival, %

Time

(months)

100

90

80

70

60

50

40

30

20

10

0

0

ENCO300 VEM

Censored patients

3 6 9 12 15 18 21 24 27 30 33 36 39

42 45 48

Patients at

risk

84

ENCO30

0

194 181 168 147 133 117 109 94 86 83 79 59 40 24 5 0 0

VEM 191 184 166 140 115 100 89 83 77 71 62 56 30 19 8 1 0

Median OS in months (95% CI)

ENCO300

VEM

23.5 (19.6–33.6)

16.9 (14.0–24.5)

HR (95% CI), 0.76 (0.58–0.98)

Nominal 2-sided

P

=0.033