37 / 116
Toxicidad BRIM-3
Chapman PB,
et al.
N Engl J Med 2011
Vemurafenib
(N=336)
Dacarbazina
(N=282)
Artralgia (%)
Grado 2
Grado 3
18
3
<1
<1
Rash (%)
Grado 2
Grado 3
10
8
0
0
Astenia (%)
Grado 2
Grado 3
11
2
12
2
Carcinomas epidermoides (%)
Grado 3
12
<1
Keratoacantomas (%)
Grado 2
Grado 3
2
6
0
0
Náuseas (%)
Grado 2
Grado 3
7
1
11
2
Alopecia (%)
Grado 2
8
0
MEK1/2
ERK
P
P
BRAF
V600
MAPK signaling
MEK1/2
ERK
P
P
BRAF
V600
BRAFi
MAPK signaling
CRAF
MEK1/2
ERK
P
P
BRAF
MAPK signaling
RAS
CRAF
MEK1/2
ERK
P
P
BRAF
BRAFi
MAPK signaling
HRAS
Q61
CRAF
CRAF
BRAF
V600 Mutant Melanoma
BRAF
Wild-Type Cells
Holderfield M, Br J Cancer 2014