18 / 43
284
202 155 119 102 90 70 23 9
1
0
278
200 138 105 83 67 43 25 11 1
0
PFS BY PD-L1 EXPRESSION:
IMDC INTERMEDIATE/POOR RISK
PD-L1 <1% (n = 562)
PD-L1 ≥1% (n = 214)
HR (95% CI) 0.48 (0.28–0.82)
P
= 0.0003
Median PFS, months (95% CI)
NIVO + IPI
22.8 (9.4
–
NE)
SUN
5.9 (4.4
–
7.1)
HR (95% CI) 1.00 (0.74–1.36)
P
= 0.9670
Median PFS, months (95% CI)
NIVO + IPI
11.0 (8.1
–
14.9)
SUN
10.4 (7.5
–
13.8)
NIVO
SUN
No. at
Risk
100 77 61 54 50 48 41 21 8
2
0
114 63 40 24 17 13 9
4
0
0
3
0.8
0.9
1.0
0.4
0.5
0.6
0.7
0
9 6 3
21
18
15
12
30
27
24
0.1
0.0
0.2
0.3
0.8
0.9
1.0
0.4
0.5
0.6
0.7
0
9 6 3
21
18
15
12
30
27
24
0.1
0.0
0.2
0.3
Progression-Free Survival (Probability)
Months
Months
Exploratory endpoint
Motzer RJ, et al. N Engl J Med 2018;378(14):1277-90