13 / 43
ORR AND DOR: IMDC INTERMEDIATE/POOR RISK
N = 847
Outcome
NIVO + IPI
N = 425
SUN
N = 422
Confirmed ORR,
a
% (95% CI)
42 (37–47) 27 (22–31)
P
< 0.0001
Confirmed BOR,
a
%
Complete response
Partial response
Stable disease
Progressive disease
Unable to determine/not reported
9
b
32
31
20
8
1
b
25
45
17
12
SUN
NIVO + IPI
No. at Risk
177
146
120
55
3
112
75
52
17
0
0.0
0.1
0.2
0.3
0.4
0.5
0.6
0.7
0.8
0.9
1.0
0
6
12
18
24
Months
Duration of Response (Probability)
Co-primary endpoint: ORR
Median duration of response,
months (95% CI)
Patients with ongoing
response, %
NIVO + IPI
NR (21.8–NE)
72
SUN
18.2 (14.8–NE)
63
Motzer RJ, et al. N Engl J Med 2018;378(14):1277-90