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Olanzapine as an Antiemetic

- Overview and Issues -

• What is its role?:

– As the 4th drug in a combination

1

?

or

– Initial therapy as a replacement for an NK

1

RA

2

?

or

– For patients who have not done well during the prior cycle?

• What is the dose?:

– 10 mg per day (US trials)

1

, 5 mg per day (Japanese trial)

3

• What is the schedule?:

– Daily for 4 days

1

?

– We are studying just 1 dose at bedtime on the evening following chemotherapy

1. Navari RM, et al.

New Engl J Med.

2016; 375: 134-142 2. Navari RM, et al.

J Clin Oncol.

2015; 33(suppl): Abst 9502 3. Hashimoto H, et al.

J Clin Oncol.

2016; 34 (suppl): Abst 10111