Olanzapine as an Antiemetic
- Overview and Issues -
• What is its role?:
– As the 4th drug in a combination
1
?
or
– Initial therapy as a replacement for an NK
1
RA
2
?
or
– For patients who have not done well during the prior cycle?
• What is the dose?:
– 10 mg per day (US trials)
1
, 5 mg per day (Japanese trial)
3
• What is the schedule?:
– Daily for 4 days
1
?
– We are studying just 1 dose at bedtime on the evening following chemotherapy
1. Navari RM, et al.
New Engl J Med.
2016; 375: 134-142 2. Navari RM, et al.
J Clin Oncol.
2015; 33(suppl): Abst 9502 3. Hashimoto H, et al.
J Clin Oncol.
2016; 34 (suppl): Abst 10111