Update and new trends in antiemetic therapy and supportive care

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DA = dopamine; GABA = gamma-aminobutyric acid; NK = neurokinin RAs = receptor antagonists
NEUROTRANSMITTERS AND ANTIEMETIC PATHWAYS:
Agents and Key Pathways Influencing Emetic Control
Highly Selective Targeted Antiemetics
- Serotonin Type 3 Receptor Antagonists (5HT3RA)
- Neurokinin Receptor Antagonists (NK1RA)
Advantages: Active and few side-effects
Less Targeted Antiemetics
- Corticosteroids (typically Dexamethasone)
- Olanzapine
Disadvantages: Off-target side-effects