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Balar, AV et al. ESMO 2016
•
PD-L1 expression in the tumor
microenvironment has been
associated with response with
PD-1 pathway inhibition
•
Combined positive score (CPS)
is determined by 22C3 PD-L1
IHC assay
•
CPS is defined as percentage
of PD-L1 positive cells relative
to the total number of tumor
cells
expression of PD-L1 appears to be
predictive for pembrolizumab