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FACT-P: mean change over time (PMM analysis)
PMM assumes data missing not at random
As expected, patients in both treatment arms experienced
meaningful decline in FACT-P total score (>10 points) over time;
the rate of decline was
significantly slower
in patients treated
with enzalutamide
PROSPER: longitudinal analysis of FACT-P total scores in
patients with M0 CRPC
Median FACT-P value over time
In PROSPER, good HRQoL was maintained during the
treatment period in both groups
Deterioration in HRQoL would be expected as patients
progress and age
PMM=pattern mixed model
Tombal B, et al. 2018 EAU Meeting, Copenhagen