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Melanoma, pulmón, vejiga, y
tumores gastrointestinales tienen
los niveles más altos de TMB
a
Variación de la TMB entre diferentes tipos tumorales
a
Analyzed using an algorithm developed to extract mutational signatures from catalogs of somatic mutations in 1600 primary cancers. TMB
assessed by whole genome sequencing and whole exome sequencing. CRC = colorectal cancer; GBM = glioblastoma multiforme; mut/Mb =
mutations per megabase; TMB = tumor mutational burden. Lawrence MS, et al.
Nature
2013;499:214–218.
9
TMB varía entre
pacientes
T h y r o id
B r e a s t
M u l t ip le m y e lo m a
K id n e y c le a r c e l l
G B M
C e r v ic a l
H e a d a n d n e c k
C R C
E s o p h a g e a l
G a s t r ic
B la d d e r
L u n g s q u a m o u s
M e la n o m a
0 .0 1
0 .1
1
1 0
1 0 0
1 0 0 0
S o m a t ic m u ta tio n fr e q u e n c y (m u t/M b )
TBM mediana varía enre tipos
tumorales
Figure adapted from from Lawrence et al, 2013,
Nature