Alterations in targetable oncogenic
pathways in NSCLC
•
There are, on average, more than 300 non-synonymous mutations per
lung cancer but only a minority of these genes can promote
tumorigenesis.
•
Large scale genomic studies have recognized a variety of potential
therapeutic targets including
–
Establish (
EGFR, ALK, ROS
1, BRAF and PD-1/PD-L1)
–
Emerging (
MET, RET, NTRK
)
–
Elusive (
TP53, KRAS
)