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Alterations in targetable oncogenic

pathways in NSCLC

There are, on average, more than 300 non-synonymous mutations per

lung cancer but only a minority of these genes can promote

tumorigenesis.

Large scale genomic studies have recognized a variety of potential

therapeutic targets including

Establish (

EGFR, ALK, ROS

1, BRAF and PD-1/PD-L1)

Emerging (

MET, RET, NTRK

)

Elusive (

TP53, KRAS

)