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sequencing strategies
•
Sequencing strategies should be flexible; in some cases revisiting previous
agents may be the best approach
Shaw AT, et al. N Engl J Med 2016;374:54−61.
Crizotinib
Chemotherapy
Lorlatinib
Crizotinib
Ceritinib AUY922
Crizotinib
Biopsy
Biopsy
Biopsy
Biopsy
Months:
6
12
18
24
30
36
42
48
Effect of therapy
Before lorlatinib
Response to lorlatinib
Resistance to lorlatinib
Response to crizotinib
C1156Y
L1198F
C1156Y