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NTRK
rearrangements
•
NTRK gene rearrangements have recently emerged as targets.
•
TRK fusions occur rarely but broadly in various adult and pediatric solid tumors,
including appendiceal cancer, breast cancer, cholangiocarcinoma, colorectal
cancer, GIST, infantile fibrosarcoma, lung cancer, mammary analogue secretory
carcinoma of the salivary gland, melanoma, pancreatic cancer, thyroid cancer, and
various sarcomas.
•
Several TRK inhibitors are now in clinical development including Larotrectinib and
Entrectinib.