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Critical aspects in implementation of liquid biopsy in the clinics

ctDNA

shedding

Intratumor

heterogeneity

Targeted

therapies

Tumor load

Met locations

Necrosis, other

biological processes

Clonality

mCRC: APC, KRAS vs

BRAF, PIK3CA

Selection

mCRC: anti-EGFR, RAS

clones

mCRC