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1º Line

TMB high

TMB low

Other

Charact.

PDL1 Neg

Chemo

Chemo-IO

Chemo

Chemo-IO

?

PDL1 ≥1%

IO

Chemo-IO

IO

Chemo-IO

Unfit for

Chemo

PDL1 ≥ 50%

IO

Chemo-IO

IO

Chemo-IO

Agressive

Disease ?

What will I do?