Secuencia de tratamiento de llegada de la inmunoterapia en CPNM metastásico

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TMB and Tumor PD-L1 Expression Identify Distinct
and Independent Populations of NSCLC
Tumor PD-L1 expression
11
aSymbols (dots) in the scatterplot may represent multiple data points, especially for patients with <1% tumor PD-L1 expression. The black line shows the relationship between TMB and PD-L1
expression as described by a linear regression model; bAmong patients in the nivolumab +ipilimumab and chemotherapy arms; TMB ≥10 mut/Mb, n = 299; TMB <10 mut/Mb, n = 380
TMB and tumor PD-L1 expressiona
PD-L1 expression (%)
TMB (number of mutations/Mb)
0
20
40
60
80
100
160
120
140
0 20 40 60 80 100
TMB ≥10 mut/Mbb
TMB <10 mut/Mbb
<1%
29%
≥1%
71%
<1%
29%
≥1%
71%
<1%
29%
≥1
<1%
29%
≥1%
71%
Hellmann et al., NEJM 2018