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Leisha A. Emens, and Gary Middleton Cancer Immunol Res 2015;3:436-443
Lorenzo Galluzzi et al. Cancer Immunol Res 2016
Immunotherapy can modify tumor micro-environment increasing
sensitivity to chemotherapy
• Reduced support to cancer cells (effect on MDSC and
macrophages)
• Reprogrammed tumor vasculature
Chemotherapy can boost the immune response
• Immunogenic cell death
• Depletion of myeloid cells & Tregs, influx of TILs, inflammation
Combining Inmunotherapy plus
Chemotherapy