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DEFINITION OF CASTRATION-RESISTANT PROSTATE CANCER
Biochemical
progression
•Three consecutive rises
in PSA 1 wk apart,
resulting in two 50%
increases over the
nadir, and PSA >2
ng/ml.
Radiological
progression
•The appearance of new
lesions: either two or
more new bone lesions
on bone scan or a soft
tissue lesion using
RECIST.
Castration serum
testosterone <
50 ng/dL or
1.7 nmol/L
Or
+
Cornford P, et al. Eur Urol 2017;71(4):630-642