25 / 43
NIVO + IPI
N = 547
SUN
N = 535
Event, %
Any grade Grade 3–5 Any grade Grade 3–5
a
Treatment-related adverse events in ≥25% of patients
93
46
97
63
Fatigue
37
4
49
9
Pruritus
28
<1
9
0
Diarrhea
27
4
52
5
Nausea
20
2
38
1
Hypothyroidism
16
<1
25
<1
Decreased appetite
14
1
25
1
Dysgeusia
6
0
33
<1
Stomatitis
4
0
28
3
Hypertension
2
<1
40
16
Mucosal inflammation
2
0
28
3
Palmar-plantar erythrodysesthesia syndrome
1
0
43
9
Treatment-related AEs leading to discontinuation, %
22
15
12
7
Treatment-related deaths
n = 7
b
n = 4
c
TREATMENT-RELATED ADVERSE EVENTS
Escudier B, et al. ESMO 2017; LBA5