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Scagliotti, et al. ESMO 2016 (Abs. LBA42); Kim, et al. Lancet Oncol 2016 17(4): 452–63; Crino, et al. J Clin Oncol 2016 34(24): 2866–73

Kim, et al. ASCO 2016 (Abs. 9007); Shaw, et al. Lancet Oncol 2016 17(2):234–42; Ou, et al. J Clin Oncol 2015 34(7): 661–8

Solomon, et al. N Engl J Med 2014 371(23): 2167–77; Felip, et al. ESMO 2016 (Abs. 1208O)

ALK

inhibitor-

naive

Post-ALK

inhibitor

31–40%

58–71%

31–44%

42–58%

27–36%

37–42%

75%

34–68%

Bone

Brain

Liver

Lung

Apparent paradox of improved survival