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The CNS is a common site of metastases in patients with
ALK
+ NSCLC
1. Costa, et al. Clin Oncol 2011
2. Guerin, et al. J Med Econ 2015; 3. Johung, et al. J Clin Oncol 2015
CNS metastases are present at diagnosis in approximately 15–35% of
patients with
ALK
+ NSCLC
2
Patients frequently present with multiple
brain metastases; approximately 50% of
patients with brain metastases at diagnosis
have ≥4 lesions
3
CNS metastases in a patient with
ALK+
NSCLC
1