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Detection of ALK fusions by IHC and FISH
IHC
RT-
PCR
FIS
H
H&E
staining
ALK, anaplastic lymphoma kinase; FISH, fluorescence in situ hybridization; H&E, hematoxylin and eosin; IHC, immunohistochemistry; RT-PCR, reverse-transcriptase polymerase
chain reaction.
From Kwak EL, et al.
N Engl J Med
. Anaplastic lymphoma kinase inhibition in non–small-cell lung cancer. 2010;363:1693-1703. Copyright © 2010 Massachusetts Medical
Society. Reprinted with permission from Massachusetts Medical Society.