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Detection of ALK fusions by IHC and FISH

IHC

RT-

PCR

FIS

H

H&E

staining

ALK, anaplastic lymphoma kinase; FISH, fluorescence in situ hybridization; H&E, hematoxylin and eosin; IHC, immunohistochemistry; RT-PCR, reverse-transcriptase polymerase

chain reaction.

From Kwak EL, et al.

N Engl J Med

. Anaplastic lymphoma kinase inhibition in non–small-cell lung cancer. 2010;363:1693-1703. Copyright © 2010 Massachusetts Medical

Society. Reprinted with permission from Massachusetts Medical Society.