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PI3K
AKT
BAD
STAT3/5
mTOR
S6K
PLC
PIP2
IP3
RAS
MEK
LrK
Cell proliferations
Cell Survival
Grande E et al. Mol Cancer Ther 2011
Bai et al. Mol Cell Biol 1998
Mossé et al. CCR 2009.
Chromosome 2p32.2
Transmembrane
protein with TK
activity
In adults expression
limited to central
nervous system
ALK Gene