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PI3K

AKT

BAD

STAT3/5

mTOR

S6K

PLC

PIP2

IP3

RAS

MEK

LrK

Cell proliferations

Cell Survival

Grande E et al. Mol Cancer Ther 2011

Bai et al. Mol Cell Biol 1998

Mossé et al. CCR 2009.

Chromosome 2p32.2

Transmembrane

protein with TK

activity

In adults expression

limited to central

nervous system

ALK Gene