ALK Actualización en terapias dirigidas en CPNM ALK+

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1. Gridelli, et al. Cancer Treat Rev 2014
2. D‘Arcangelo, et al. Curr Opin Oncol 2013
3. Hallberg, et al. Nat Rev Cancer 2013; Ou, et al. Oncologist 2012
The most common rearrangement is between
EML4 and ALK, which produces the
EML4-ALK-fusion protein1,2
EML4
13 6 14 15 20 17 18 2
Breakpoint at
exon:
The breakpoint within EML4 can differ, thus
generating different variants of the
fusion protein 1,2
Breakpoints within EML41,2
The breakpoint within ALK occurs at
exon 20 (A20)1,2
Exon A20
Summary of common variants
of the ALK-fusion protein1–4
ALK EML4
ALK EML4
ALK EML4
ALK EML4
ALK EML4
ALK EML4
ALK EML4
ALK EML4
ALK KIF5B
ALK TFG
ALK KLC1
ALK PTPN3
ALK STRN
Fusion protein Variant
Frequency
in ALK+
NSCLC
E13:A20 33%
E6a/b:A20 29%
E20:A20 9%
E14:A20 3%
E18:A20 2%
E15:A20 2%
E2:A20 2%
E17:A20 1%
0.5%
Unknown %
ALK fusion partners in NSCLC