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Phase III placebo-controlled blinded randomized international study
Smith et al. Apalutamide Treatment and Metastasis-free Survival in Prostate Cancer. N Engl J Med. 2018 Apr 12;378(15):1408-1418.
SPARTAN phase III trial
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Secondary end points (hierarchical testing):
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Time to metastasis
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Progression-free survival (PFS)
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Time to symptomatic progression
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Overall survival (OS)
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Time to cytotoxic chemotherapy