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Why is M0 CRPC important?
•
Men with M0 CRPC + PSA-DT <8-10 months
are at significant
risk for M1
disease and PCa-
specific death.
•
Metastases are a major cause of
morbidity
and
mortality
.
•
There are
no approved
treatments for patients
with M0 CRPC.
•
Prevention of M1 represents an important
unmet medical need
in these patients.
Smith M et al. Denosumab and bone-metastasis-free survival in men with castration-resistant prostate cancer: results of a phase 3, randomised, placebo-controlled trial. Lancet 2013; 379: 39-46