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PALOMA-2: Perfil de toxicidad hematológica
•
Grade 3/4 febrile neutropenia was reported in 1.8% of patients in the palbociclib + letrozole arm vs. 0% in the
placebo + letrozole arm
Finn RS, et al.
N Engl J Med
2016;375(20):1925–36
Palbociclib + letrozole
(N=444)
Placebo + letrozole
(N=222)
Any
grade Grade 3 Grade 4 Any grade Grade 3 Grade
4
Any AE, %
98.9
62.2
13.5
95.5
22.1
2.3
Neutropenia
a
79.5
56.1
10.4
6.3
0.9
0.5
Leukopenia
a
39.0
24.1
0.7
2.3
0
0
Anemia
a
24.1
5.2
0.2
9.0
1.8
0
Thrombocytop
a
15.5
1.4
0.2
1.4
0
0
PALBOCICLIB
Toxicidad