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Primera Señal en estudio PALOMA-3
0
6
12
18
24
30
36
42
48
54
Time (Month)
0
10
20
30
40
50
60
70
80
90
100
Overall Survival Probability (%)
Palbociclib+Fulvestrant (N=347)
Median OS=34.9 months
95% CI (28.8, 40.0)
Placebo+Fulvestrant (N=174)
Median OS=28.0 months
95% CI (23.6, 34.6)
Stratified HR=0.814
95% CI (0.644, 1.029)
1-sided p=0.0429
Unstratified HR=0.791
95% CI (0.626, 0.999)
1-sided p=0.0246
347
321
286
247
209
165
148
126
17
PAL+FUL
174
155
135
115
86
68
57
43
7
PBO+FUL
Number of patients at risk
Palbociclib
CMM RE[+]