27 / 34
a
Palbociclib + fulvestrant arm only;
b
By episode by grade analysis. Percentages are based on number of episodes in each subgroup. For
multiple time to recovery periods within a subject, average was taken prior to summarizing across subjects
Data cutoff March 16 2015 used for final analysis; median follow-up 8.9 months
Time to onset of haematological toxicity
a
Duration of each episode
a
Grade ≥3
Grade 4
0
40
20
10
50
60
30
Thrombocytopenia
Anemia
Neutropenia
Median (range) time to onset from
first dose of palbociclib to first episode (days)
0.0 (0–0)
16.0 (13–293)
17.0 (13–147)
39.5 (15–225)
26.5 (15–92)
15.0 (15–24)
0
8
6
1
9 10
7
Median (range) duration of each episode (days)
2 3 4 5
Thrombocytopenia
Anemia
Neutropenia
0.0 (0–0)
b
7.0 (1–98)
b
8.0 (1–15)
b
7.0 (1–141)
b
7.0 (1–27)
b
7.0 (1–8)
b
•
The median times from first palbociclib dose to onset of any-grade neutropenia was 15 days (range, 13–140 days)
•
Median time from first dose to lowest ANC reported on study was 29 days (range, 13–334 days)
1. Verma S, et al.
Oncologist
2016
Palbociclib: Las toxicidades hematológicas aparecen
pronto y son recortadas enel tiempo