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Talazoparib improves PFS and ORR in gBRCAm MBC
EMBRACA
Talazoparib 1mg/d
TPC (Cape, VNR, Erib, GEM)
gBRCAm MBC
<3 previous lines
Litton J. SABCS 2017
Randomise 2:1
N=431
Stratification by
•
# of prior chemo regimens (0 or ≥ 1)
•
TNBC or HR+
•
CNS mets or no CNS mets
TALA
(n = 287)
PCT
(n = 144)
Events (%)
186 (65%)
83 (58%)
mPFS
8.6 m
5.6 m
Hazard ratio, 0.54,
95% (0.41, 0.71)
P
< .0001
TALA
(n = 287)
PCT
(n = 144)
ORR
62.7%
27.2%
P
< .0001