15 / 24
Health-related quality of life: FACT-O TOI score*
Olaparib
Placebo
Change from baseline
in TOI score
Weeks since randomization
218
115
204
114
No. at risk
Olaparib
Placebo
35
30
25
20
15
10
5
0
-
40
-35
-
30
-25
-20
-15
-10
-5
13
25 37 49 61 73 85 97
191
104
186
91
179
75
163
61
144
51
141
49
137
42
5
*TOI scores range from 0 to 100, with higher scores indicating better HRQoL and a clinically meaningful difference defined as ±10 points
The difference between
olaparib and placebo in
the mean change from
baseline in TOI score
over 24 months (−3.00;
95% CI −4.779, −1.216)
was not clinically
meaningful
Figure reproduced from: Moore K
et al
.
N Engl J Med
2018; 379(26):2495–505