Update and new trends in antiemetic therapy and supportive care

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5HT3 DEX APR
5HT3 DEX APR
PALO DEX
DEX
+ +
+ +
+
5HT3 =
serotonin receptor
antagonist
DEX =
DEXAMETHASONE
NK1 =
neurokinin receptor
antagonist
A Modest Proposal for Updating Antiemetic Risk Categories by Chemotherapy for
Guideline Use: Acute Emesis
EMETIC RISK GROUP ANTIEMETICS
High
Moderately-High (60% -90%)…ie AC,
Carbo, possibly Oxaliplatin, more…
Moderate (other than AC)
Low
Minimal No routine prophylaxis
5HT3 DEX NK1
5HT3 DEX NK1
DEX
DEX
* Some groups / experts prefer palonosetron
5HT3 DRA
DRA =
dopamine receptor
antagonist
+ +
OR
+
+
OR
+
Based on: Roila F, et al. Ann Oncol. 201627(suppl 5):v119-v133. Basch E, et al. J Clin Oncol. 2016;34(6):557-565.
* Consider Olazapine in: The highest risk groups (Cisplatin/AC…especially in younger women, and in those who did not do well with the initial
chemotherapy
5HT3 *
±Olanzapine*