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Proliferative inhibition
of
BRAF inhibitors
In vitro
analysis of the impact of BRAFi on cell
proliferation in different BRAF mutant cell lines:
-
IC50
is the concentration needed to inhibits 50% of
cell proliferation
4 000
1 000
400
100
40
10
4
IC
50
(μM)
BRAF V600E mutant
BRAF V600O/K mutant
Stuart DD, et al. AACR. 2012: abstract 3790