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Residual viable tumor as a surrogate for
survival…
§
Degree of pathologic response
§
60% vs < 60%
: Overall Survival: 61 months vs 22 months
(Betticher
DC,et al. British Journal of Cancer. Apr 24; 2006)
§
Recently, a study, only pathologic stage and pathologic response
(<10% viable tumor) associated with overall survival in multivariate
analysis (
HR=2.39, p:0.05 if > 10% viable tumor
)
(Pataer et al. JTO
2012, William et al. JTO 2013)
§
50 patients with stage IB-IIIA were treated with neoadjuvant
chemotherapy and bevacizumab.
22% patients had <10%
viable
tumor:
100% were alive three years
, compared to only 49% of
those who had resection but >10% residual tumor
(
Chaft et al. JTO
2013)