52 / 59
Smith MR, et al. N Engl J Med 2018;378:1408-18
Table S5.
Causes of Death.
Apalutamide
(n=803)
Placebo
(n=398)
no. of patients (%)
All deaths within 28 days of last dose
10 (1.2)
1 (0.3)
Adverse event
7 (0.9)
1 (0.3)
Death due to prostate cancer
3 (0.4)
0
Other
0
0
Adverse events leading to death
10
1
Acute myocardial infarction
1 (0.1)
0
Cardio-respiratory arrest
1 (0.1)
1 (0.3)
Cerebral hemorrhage
1 (0.1)
0
Myocardial infarction
1 (0.1)
0
Multiple organ dysfunction
1 (0.1)
0
Pneumonia
1 (0.1)
0
Prostate cancer
2 (0.2)
0
Sepsis
2 (0.2)
0
SPARTAN – CAUSES OF DEATH