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Table S2. Cause of Death* without Evidence of Radiographic Progression
Enzalutamide
(N=933)
Placebo
(N=468)
Total — no. (%)
32 (3)
4 (1)
Cause — no. (%)
Cardiovascular event
†
Pneumonia
‡
Stroke
§
General physical health deterioration
║
Hemorrhage
¶
Unknown**
Mesenteric vein thrombosis
Interstitial lung disease
Pleurisy
Respiratory tract infection
Septic shock
Brain neoplasm
Sudden death
Chronic obstructive pulmonary disease
Pancreatic carcinoma
11 (1)
4 (<1)
3 (<1)
3 (<1)
2 (<1)
2 (<1)
1 (<1)
1 (<1)
1 (<1)
1 (<1)
1 (<1)
1 (<1)
1 (<1)
0
0
1 (<1)
0
0
1 (<1)
0
0
0
0
0
0
0
0
0
1 (<1)
1 (<1)
* Death from randomization to within 112 days of treatment discontinuation.
†
Includes acute myocardial infarction, myocardial infarction, cardiac failure, sudden
PROSPER – CAUSES OF DEATH WITH NO EVIDENCE OF RADIOGRAPHIC
PROGRESSION
Hussain M, et al. N Engl J Med 2018;378:2465-74